Bienvenue sur le site de l'Institut Fédératif de Recherche n°66. .
Structures Fédératives de Recherche

Rapport d'évaluation par l'AERES de la SFR TransBioMed

Journée Scientifique de l'IFR66

 

Mardi 7 et Mercredi 8 Décembre 2010

 

Invités :

Jules HOFFMANN
Président de l’Académie des Sciences à Paris

Kari ALITALO
Academy Professor
Molecular Cancer Biology Program
Biomedicum Helsinki

 

Focus sur quelques publications récentes de l'IFR 66 :
The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. Reigadas S, Anies G, Masquelier B, Calmels C, Stuyver LJ, Parissi V, Fleury H, Andreola ML.
(CNRS UMR 5234 )puce
Hijacking Hepatitis C viral replication with a non-coding replicative RNA. Bitard J, Chognard G, Dumas E, Rumi J, Masante C, Mahias K, Astier-Gin T, Ventura M.(CNRS UMR 5234 )puce In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence.
Ménard L, Taras D, Grigoletto A, Haurie V, Nicou A, Dugot-Senant N, Costet P, Rousseau B, Rosenbaum J.
(INSERM U 889)puce

Nucleoporin 153 arrests the nuclear import of hepatitis B virus capsids in the nuclear basket.
Schmitz A, Schwarz A, Foss M, Zhou L, Rabe B, Hoellenriegel J, Stoeber M, Panté N, Michael Kann M
(CNRS UMR 5234 )puce
 

Dernières Publications de L'IFR66

Laboratoire CNRS UMR 5234

The Candida albicans Rgd1 is a RhoGAP protein involved in the control of filamentous growth.
Ness F, Prouzet-Mauleon V, Vieillemard A, Lefebvre F, Noël T, Crouzet M, Doignon F, Thoraval D.
Fungal Genet Biol. 2010 Jul 14. [Epub ahead of print]PMID: 20637818 [PubMed - as supplied by publisher]Related citations

Molecular Mechanisms of Resistance to 5-Fluorocytosine in Laboratory Mutants of Candida glabrata.
Vandeputte P, Pineau L, Larcher G, Noel T, Brèthes D, Chabasse D, Bouchara JP.
Mycopathologia. 2010 Jul 9. [Epub ahead of print]PMID: 20617462 [PubMed - as supplied by publisher]Related citations

Intron RNA editing is essential for splicing in plant mitochondria.
Castandet B, Choury D, Bégu D, Jordana X, Araya A.
Nucleic Acids Res. 2010 Jul 8. [Epub ahead of print]PMID: 20615898 [PubMed - as supplied by publisher]Free ArticleRelated citations

A complexomic study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism.
Bernarde C, Lehours P, Lasserre JP, Castroviejo M, Bonneu M, Megraud F, Menard A.
Mol Cell Proteomics. 2010 Jul 7. [Epub ahead of print]PMID: 20610778 [PubMed - as supplied by publisher]Free ArticleRelated citations

CTX-M-producing Escherichia coli in a maternity ward: a likely community importation and evidence of mother-to-neonate transmission.
Dubois V, De Barbeyrac B, Rogues AM, Arpin C, Coulange L, Andre C, M'zali F, Megraud F, Quentin C.
J Antimicrob Chemother. 2010 Jul;65(7):1368-71. Epub 2010 May 13.PMID: 20466850 [PubMed - in process]Related citations

The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.
Reigadas S, Anies G, Masquelier B, Calmels C, Stuyver LJ, Parissi V, Fleury H, Andreola ML.
PLoS One. 2010 Apr 26;5(4):e10311.PMID: 20436677 [PubMed - in process]Free PMC ArticleFree textRelated citations

Laboratoire EA 3671

First report of a Klebsiella oxytoca septic arthritis.
Ménard A, Harambat J, Pereyre S, Pontailler JR, Mégraud F, Richer O.
J Clin Microbiol. 2010 Jun 23. [Epub ahead of print]PMID: 20573877 [PubMed - as supplied by publisher]Related citations

CTX-M-producing Escherichia coli in a maternity ward: a likely community importation and evidence of mother-to-neonate transmission.
Dubois V, De Barbeyrac B, Rogues AM, Arpin C, Coulange L, Andre C, M'zali F, Megraud F, Quentin C.
J Antimicrob Chemother. 2010 Jul;65(7):1368-71. Epub 2010 May 13.PMID: 20466850 [PubMed - in process]Related citations

Laboratoire INSERM U 920

Synchrotron radiation FTIR imaging in minutes: a first step towards real-time cell imaging.
Petibois C, Cestelli-Guidi M, Piccinini M, Moenner M, Marcelli A.
Anal Bioanal Chem. 2010 Jul;397(6):2123-9. Epub 2010 Jun 2.PMID: 20517599 [PubMed - in process]Related citations

A combined metabonomic and transcriptomic approach to investigate metabolism during development in the chick chorio-allantoic membrane.
Cavill R, Sidhu J, Kilarski W, Javerzat S, Hagedorn M, Ebbels T, Bikfalvi A, Keun HC.
J Proteome Res. 2010 May 5. [Epub ahead of print]PMID: 20443636 [PubMed - as supplied by publisher]Related citations

Laboratoire INSERM U 876

Modeling of congenital erythropoietic porphyria by RNA interference: a new tool for preclinical gene therapy evaluation.
Robert-Richard E, Lalanne M, Lamrissi-Garcia I, Guyonnet-Duperat V, Richard E, Pitard V, Mazurier F, Moreau-Gaudry F, Ged C, de Verneuil H.
J Gene Med. 2010 Jun 29. [Epub ahead of print]PMID: 20586119 [PubMed - as supplied by publisher]Related citations

Nilotinib is active in chronic and accelerated phase chronic myeloid leukemia following failure of imatinib and dasatinib therapy.
Giles FJ, Abruzzese E, Rosti G, Kim DW, Bhatia R, Bosly A, Goldberg S, Kam GL, Jagasia M, Mendrek W, Fischer T, Facon T, Dünzinger U, Marin D, Mueller MC, Shou Y, Gallagher NJ, Larson RA, Mahon FX, Baccarani M, Cortes J, Kantarjian HM.
Leukemia. 2010 Jul;24(7):1299-301. Epub 2010 Jun 3.PMID: 20520639 [PubMed - in process]Related citations

Loss of the Y chromosome in Philadelphia-positive cells predicts a poor response of chronic myelogenous leukemia patients to imatinib mesylate therapy.
Lippert E, Etienne G, Mozziconacci MJ, Laibe S, Gervais C, Girault S, Gachard N, Tigaud I, Dastugue N, Huguet F, Fort MP, Legros L, Eclache V, Mahon FX.
Haematologica. 2010 Apr 30. [Epub ahead of print]PMID: 20435623 [PubMed - as supplied by publisher]Free ArticleRelated citations

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM, Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA.
N Engl J Med. 2010 May 6;362(18):1686-97. Epub 2010 Apr 21.PMID: 20410501 [PubMed - indexed for MEDLINE]Related citations

Laboratoire EA 2968

Evaluation of the genotypic prediction of HIV-1 coreceptor use versus a phenotypic assay and correlation with the virological response to maraviroc: the ANRS GenoTropism study.
Recordon-Pinson P, Soulié C, Flandre P, Descamps D, Lazrek M, Charpentier C, Montes B, Trabaud MA, Cottalorda J, Schneider V, Morand-Joubert L, Tamalet C, Desbois D, Macé M, Ferré V, Vabret A, Ruffault A, Pallier C, Raymond S, Izopet J, Reynes J, Marcelin AG, Masquelier B; ANRS AC11 Resistance Study Group.
Antimicrob Agents Chemother. 2010 Aug;54(8):3335-40. Epub 2010 Jun 7.PMID: 20530226 [PubMed - in process]Related citations

The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.
Reigadas S, Anies G, Masquelier B, Calmels C, Stuyver LJ, Parissi V, Fleury H, Andreola ML.
PLoS One. 2010 Apr 26;5(4):e10311.PMID: 20436677 [PubMed - in process]Free PMC ArticleFree textRelated citations

HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens.
da Silva D, Van Wesenbeeck L, Breilh D, Reigadas S, Anies G, Van Baelen K, Morlat P, Neau D, Dupon M, Wittkop L, Fleury H, Masquelier B.
J Antimicrob Chemother. 2010 Jun;65(6):1262-9. Epub 2010 Apr 12.PMID: 20388636 [PubMed - in process]Related citations

Laboratoire EA 4135

Structure-activity relationship of human liver-expressed antimicrobial peptide 2.
Hocquellet A, Odaert B, Cabanne C, Noubhani A, Dieryck W, Joucla G, Le Senechal C, Milenkov M, Chaignepain S, Schmitter JM, Claverol S, Santarelli X, Dufourc E, Bonneu M, Garbay B, Costaglioli P.
Peptides. 2009 Oct 21. PMID: 19852990 Related articles

Laboratoire INSERM U853

Combined approach with infliximab, surgery, and methotrexate in severe fistulizing anoperineal crohn's disease: Results from a prospective study.
Roumeguère P, Bouchard D, Pigot F, Castinel A, Juguet F, Gaye D, Capdepont M, Zerbib F, Laharie D.
Inflamm Bowel Dis. 2010 Jul 8. [Epub ahead of print]PMID: 20623697 [PubMed - as supplied by publisher]Related citations

A complexomic study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism.
Bernarde C, Lehours P, Lasserre JP, Castroviejo M, Bonneu M, Megraud F, Menard A.
Mol Cell Proteomics. 2010 Jul 7. [Epub ahead of print]PMID: 20610778 [PubMed - as supplied by publisher]Free ArticleRelated citations

Clinical relevance and diversity of two homologous genes encoding glycosyltransferases in Helicobacter pylori.
Oleastro M, Santos A, Cordeiro R, Nunes B, Mégraud F, Ménard A.
J Clin Microbiol. 2010 Jun 16. [Epub ahead of print]PMID: 20554820 [PubMed - as supplied by publisher]Related citations

From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma.
Thiberge JM, Boursaux-Eude C, Lehours P, Dillies MA, Creno S, Coppée JY, Rouy Z, Lajus A, Ma L, Burucoa C, Ruskoné-Foumestraux A, Courillon-Mallet A, De Reuse H, Boneca IG, Lamarque D, Mégraud F, Delchier JC, Médigue C, Bouchier C, Labigne A, Raymond J.
BMC Genomics. 2010 Jun 10;11:368.PMID: 20537153 [PubMed - in process]Free ArticleRelated citations

Allelic diversity among helicobacter pylori outer membrane protein genes homB and homA generated by recombination.
Oleastro M, Cordeiro R, Ménard A, Gomes JP.
J Bacteriol. 2010 Aug;192(15):3961-8. Epub 2010 Jun 4.PMID: 20525831 [PubMed - in process]Related citations

Matrix-assisted laser-desorption/ionization biotyper: experience in the routine of a University hospital.
Bessède E, Angla-Gre M, Delagarde Y, Sep Hieng S, Ménard A, Mégraud F.
Clin Microbiol Infect. 2010 May 27. [Epub ahead of print]PMID: 20518792 [PubMed - as supplied by publisher]Related citations

Helicobacter pylori cagA and vacA genotypes in Cuban and Venezuelan populations.
Ortiz-Princz D, Guariglia-Oropeza V, Avila M, Correnti M, Perrone M, Gutierrez B, Torres J, Megraud F, Cavazza ME.
Mem Inst Oswaldo Cruz. 2010 May;105(3):331-5.PMID: 20512250 [PubMed - in process]Free ArticleRelated citations

Detection of Campylobacter jejuni by culture and real-time PCR in a French cohort of patients with Guillain-Barre syndrome.
Sivadon-Tardy V, Orlikowski D, Porcher R, Ronco E, Caudie C, Roussi J, Fauchère JL, Mégraud F, Tabor H, Sharshar T, Annane D, Raphaël JC, Gaillard JL.
J Clin Microbiol. 2010 Jun;48(6):2278-81. Epub 2010 Apr 21.PMID: 20410350 [PubMed - in process]Related citations

Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses.
Mane SP, Dominguez-Bello MG, Blaser MJ, Sobral BW, Hontecillas R, Skoneczka J, Mohapatra SK, Crasta OR, Evans C, Modise T, Shallom S, Shukla M, Varon C, Mégraud F, Maldonado-Contreras AL, Williams KP, Bassaganya-Riera J.
J Bacteriol. 2010 Jun;192(12):3078-92. Epub 2010 Apr 16.PMID: 20400544 [PubMed - indexed for MEDLINE]Related citations

Laboratoire EA 2406

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, Briot A, Gonthier M, Lamant L, Dubus P, Monsarrat B, Hovnanian A.
J Clin Invest. 2010 Mar 1;120(3):871-82. doi: 10.1172/JCI41440. Epub 2010 Feb 22.PMID: 20179351

Laboratoire UMR CNRS 5164

Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen.
Guitart A, Hammoud M, Dello Sbarba P, Ivanovic Z, Praloran V.
Exp Hematol. 2010 Jun 12. [Epub ahead of print]PMID: 20547202 [PubMed - as supplied by publisher]Related citations

Obtaining of CD34+ cells from healthy blood donors: development of a rapid and efficient procedure using leukoreduction filters.
Peytour Y, Guitart A, Villacreces A, Chevaleyre J, Lacombe F, Ivanovic Z, Praloran V.
Transfusion. 2010 May 7. [Epub ahead of print]PMID: 20456706 [PubMed - as supplied by publisher]Related citations

Obtaining of CD34+ cells from healthy blood donors: development of a rapid and efficient procedure using leukoreduction filters.
Peytour Y, Guitart A, Villacreces A, Chevaleyre J, Lacombe F, Ivanovic Z, Praloran V.
Transfusion. 2010 May 7. [Epub ahead of print]PMID: 20456706 [PubMed - as supplied by publisher]Related citations

Laboratoire INSERM U 916

A review of PARP inhibitors: from bench to bedside.
Underhill C, Toulmonde M, Bonnefoi H.
Ann Oncol. 2010 Jul 19. [Epub ahead of print]PMID: 20643861 [PubMed - as supplied by publisher]Related citations

Gene expression profile predicts outcome after anthracycline-based adjuvant chemotherapy in early breast cancer.
Bertucci F, Borie N, Roche H, Bachelot T, Le Doussal JM, Macgrogan G, Debono S, Martinec A, Treilleux I, Finetti P, Esterni B, Extra JM, Geneve J, Hermitte F, Chabannon C, Jacquemier J, Martin AL, Longy M, Maraninchi D, Fert V, Birnbaum D, Viens P.
Breast Cancer Res Treat. 2010 Jun 29. [Epub ahead of print]PMID: 20585850 [PubMed - as supplied by publisher]Related citations

Is it useful to detect lymphovascular invasion in lymph node-positive patients with primary operable breast cancer?
Ragage F, Debled M, MacGrogan G, Brouste V, Desrousseaux M, Soubeyran I, de Lara CT, Mauriac L, de Mascarel I.
Cancer. 2010 Jul 1;116(13):3093-101.PMID: 20564641 [PubMed - indexed for MEDLINE]Related citations

Addition of lomustine to idarubicin and cytarabine improves the outcome of elderly patients with de novo acute myeloid leukemia: a report from the GOELAMS.
Pigneux A, Harousseau JL, Witz F, Sauvezie M, Bene MC, Luquet I, Hunault-Berger M, Recher C, Lioure B, Himberlin C, Escoffre-Barbe M, Berthou C, Lissandre S, Fegueux N, Cahn JY, Jourdan E, Dreyfus F, Reiffers J, Milpied N, Ifrah N.
J Clin Oncol. 2010 Jun 20;28(18):3028-34. Epub 2010 May 17.PMID: 20479424 [PubMed - indexed for MEDLINE]Related citations

Higher incidence of relapse for acute myelocytic leukemia patients infused with higher doses of CD34+ cells from leukapheresis products autografted during the first remission.
Gorin NC, Labopin M, Reiffers J, Milpied N, Blaise D, Witz F, de Witte T, Meloni G, Attal M, Bernal T, Rocha V.
Blood. 2010 May 17. [Epub ahead of print]PMID: 20479285 [PubMed - as supplied by publisher]Related citations

Variables with time-varying effects and the Cox model: some statistical concepts illustrated with a prognostic factor study in breast cancer.
Bellera CA, MacGrogan G, Debled M, de Lara CT, Brouste V, Mathoulin-Pélissier S.
BMC Med Res Methodol. 2010 Mar 16;10:20.PMID: 20233435 [PubMed - in process]Free PMC ArticleFree textRelated citations

Laboratoire INSERM U 889

Invadosomes: Intriguing structures with promise.
Saltel F, Daubon T, Juin A, Ganuza IE, Veillat V, Génot E.
Eur J Cell Biol. 2010 Jul 3. [Epub ahead of print]PMID: 20605056 [PubMed - as supplied by publisher]Related citations

Sodium fluoride induces podosome formation in endothelial cells.
Tatin F, Grise F, Reuzeau E, Genot EM, Moreau V.
Biol Cell. 2010 May 26. [Epub ahead of print]PMID: 20504277 [PubMed - as supplied by publisher]Related citations

Feasibility of liver transient elastography with FibroScan(R) using a new probe for obese patients.
de Lédinghen V, Vergniol J, Foucher J, El-Hajbi F, Merrouche W, Rigalleau V.
Liver Int. 2010 May 14. [Epub ahead of print]PMID: 20492500 [PubMed - as supplied by publisher]Related citations

Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.
Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M.
PLoS Biol. 2010 Apr 13;8(4):e1000355.PMID: 20405001 [PubMed - in process]Free PMC ArticleFree textRelated citations

Laboratoire INSERM U 869

A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.
Gomez D, Guédin A, Mergny JL, Salles B, Riou JF, Teulade-Fichou MP, Calsou P.
Nucleic Acids Res. 2010 Jun 22. [Epub ahead of print]PMID: 20571083 [PubMed - as supplied by publisher]Free ArticleRelated citations

Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection.
Ceballos C, Khiati S, Prata CA, Zhang XX, Giorgio S, Marsal P, Grinstaff MW, Barthélémy P, Camplo M.
Bioconjug Chem. 2010 Jun 16;21(6):1062-9.PMID: 20481514 [PubMed - in process]Related citations

Glycosyl-nucleoside-lipid based supramolecular assembly as a nanostructured material with nucleic acid delivery capabilities.
Godeau G, Bernard J, Staedel C, Barthélémy P.
Chem Commun (Camb). 2009 Sep 14;(34):5127-9. Epub 2009 Jul 17.PMID: 20448968 [PubMed - in process]Related citations

Lettre d'information
'IFR66 n° 12
Mai 2010

SUPRABIO
Bordeaux
14th/15th october 2010

SOS IFR66

Pour toutes vos recherches au sein
de l'IFR

 
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